New Cancer Discovery Shows How Tumor Cells Survive

New Cancer Discovery
New Cancer Discovery Shows How Tumor Cells Survive--Validates Aspirin-type Drugs
Either because they didn't understand it or because they don't concern themselves with science as (opposed to hype,) the media and the medical establishment ignored the momentous l983 discovery of how tumor cells evade destruction by the body's immune system.

As James Goodwin and J. Ceuppens* then pointed out, tumor cells cause our macrophages to produce a substance called Prostaglandin E2 (PGE2), which by the way, is inhibited by aspirin, that reduces the responsiveness of T-cells that would ordinarily kill them.

Now** eight scientists from the National Cancer Institute and the National Institute of Deafness (govt.) and P & G, Cincinnati, Ohio, have found the particular body substance that PGE2 activates that weakens our immune defenders. This factor, IL-6, like PGE2 is inflammatory. This puts it all together, one might say, in showing that EXCESSIVE INFLAMMATION may be a root cause in the promulgation of cancer.

They made this discovery while testing a new aspirin-like drug, ketorolac, purported to be less irritating to the stomach than aspirin though having the same protective effect.

DETAILS:
Tsujii, Kawano & DuBois in the journal Cell, vol. 83, l998 also showed the role of PGE2 in promoting the spread of cancer cells. Chan, Morin, Vogelstein and Kinzler, Proc. Natl. Acad. Sci USA, same issue of this journal, showed that the aspirin type drugs induce "normalization" of tumor cells, called apoptosis.

*Journal of Clinical Immunology, vol. 3. Goodwin is Head of Gerontology, U. of Texas Med Branch, Galveston.

**FASEB Journal, vol.14, 2000.

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