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Risk of
Fractures in Elderly Patients Taking Warfarin (Coumadin)
"Background:
Vitamin K 'produces an effect in the body] that activates clotting
factors and bone proteins. Vitamin K antagonists such as warfarin 'coumadin]
inhibit this process. Our goal was to quantify the association between warfarin
and osteoporotic fractures in patients with 'irregular heartbeat.]"
Editor's note: Patients with irregular heartbeat (atrial fibrilation,)
are often given warfarin instead of aspirin* or alternative medicine. In
this study, 7587 patients who were not prescribed warfarin were compared
with 4461 patients who were given the drug.
"Conclusion:
Long-term use of warfarin was associated with osteoporotic fractures, at
least in those with atrial fibrilation."
*Aspirin has been found to be somewhat less effective against irregular
heartbeat while causing fewer side effects. Needless to say, alternative
medicine is often dismissed out of hand.
From:
Archives of Internal Medicine (pub. by the A.M.A..) vol. 166, 2006.
By:
Drs. Gage, Birman-Deych, Binder, et al., Div's. of Gen. Med. Sciences,
and Geriatric and Nutritional Science, Wash. U. School of Med., St.
Louis, MO.
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