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HERBS FOR DEPRESSION?
The
herb St. John's Wort is often taken for depression by those wishing to avoid
drugs which can cause side effects, some of them serious.
The
aim of both the drugs (popular ones are termed "serotonin re-uptake
inhibitors,") and the herbs is to reduce or limit serotonin in the body. As
for
St. John's Wort,
Schempp, Winghofer, Muller, Simon, et al., of the U. of Freiburg,
Germany*, refuted one feared side effect, that of dermatitis--skin
inflammation.
Butterweck, Christoffel, Winterhoff, et al., U. of Munster, Germany** found
that ingredients other than the often-ascribed "Hypericin" ingredient in
St.
John's Wort
contribute to its anti-depressant activity. Dr. Butterweck in amplification
of this study, wrote in another journal that, "Extracts of 'St. John's Wort]
are now
successfully
competing for status as a standard antidepressant therapy." Emphasis added.
Draves & Walker, Dept. of Pharmacy, Sunnybrook & Women's College Health
Science Centre, Toronto, Canada,*** found that consistency of ingredients in
St. John's Wort tablets is often poor and over-stated. Thus some failures of
treatment may be related to under-dosage.
Hostanska, Reichling, Saller, et al.,**** found that two constituents of the
herb have toxic effects on tumor cells, especially leukemia, and inhibit the
growth of other tumor cells. While it is too early to suggest that St.
John's Wort be used as therapy for such as leukemia, it is a heartening
discovery.
Meanwhile, cautionary note by Glisson, Rogers, Khan, et al.,***** observed
that, "Health food store employees offer health care advice regarding
treatment of depression with dietary supplements without proper scientific
and medical training. Their comments could cause significant harm to
customers."
*Phytotherapy
Res., vol. 17, 2003. Second journal referred to was CNS Drugs, vol. 17,
2003.
**Life Sciences, vol. 73, 2003.
***Canadian Journal of Clinical Pharmacology, vol.10, 2003.
****European Journal of Pharma. Biopharmacy, vol. 56, 2003. Authors in the
Dept. of Internal Med., Univ. Hospital, Zurich, Switz.
*****Pharmacotherapy, vol. 23, 2003. Authors were in the Dept. of Internal
Med., U. of Miss. Med. Center, Jackson, 39216.
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to Herbs index

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