A survey of medical science in the use of Alpha-Lipoic Acid.
"Obesity shortens life expectancy and is a risk factor for hypertension and Type 2 diabetes. When added to the standard chow of 'animals]...'as 5% of total,] it reduced body weight and food intake. Alpha-lipoic acid also increased whole-body energy expenditure...Long term studies to determine whether these anti-obesity effects are maintained in animals are required before alpha-lipoic acid is considered for clinical trial in human obesity." 1 Emphasis added.
"The well-known OH+ free radical* scavenging properties of alpha-lipoic
(ALA) cannot easily be utilized for biological experiments because the
compound is practically insoluble in water. We elaborated a simple method of
preparing its Na-salt 'sodium salt] (Na-ALA) which proved to be water
"'The results of our subsequent experiments] indicate that the geriatric topical 'skin] application of Na-ALA may have an established rationale 'against oxygen radical damage in aging.] 2
*Free radicals in the body destroy healthy tissue.
"Free radical-mediated damage to 'nerve] membrane components has been implicated in the 'development] of Alzheimer's disease (AD) and aging...Our previous studies reported higher oxidative stress markers 'evidence of free radical activity in animals exhibiting symptoms similar to Alzheimer's.]...Further, we have previously shown that injecting the 'animals] with alpha-lipoic acid (LA) reversed...the learning and memory impairments in the 'animals.]" Emphasis added. 3
"...since the development of hypertension could either be totally prevented or markedly 'reduced] by...treatment potent antioxidative therapies such as alpha lipoic acid or aspirin... Moreover, the development of insulin resistance, which is associated to the model of glucose 'sugar] induced hypertension, was also found to be prevented by chronic antioxidant therapies thus suggesting that oxidative stress 'which is caused by the action of oxygen radicals] plays an important role as well in the development of insulin resistance and type 2 diabetes.
"In conclusion...our studies suggest that the chronic treatment with appropriate antioxidative therapies 'including alpha lipoic or aspirin] could prevent the development of hypertension and diabetes as well as their complications in various experimental models of hypertension." Emphasis added. 4
"Conclusion: These results 'stated earlier in the report,] suggest that oxidative stress plays an important role in asthmatic airway inflammation and that alpha-lipoic acid may be useful as 'additional] therapy for bronchial asthma." 5
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"Atherosclerotic plaque contains apoptotic 'programmed cell death] endothelial 'cells lining blood vessels] implicated in 'the process of unwanted cell death.] Vitamin E and alpha-lipoic acid are a potent antioxidant combination with the potential to prevent 'endothelial cell death]...
"Cultured bovine endothelial cells incubated for 24 hours with vitamin E and/or alpha-lipoic acid showed the combination of the two antioxidants increased a 'gene that is anti-cell death, Bcl-2] to a greater extent than cells incubated...'without them.]
"In summary, vitamin E and alpha-lipoic acid increase the endothelial cell Bcl-2, which may provide increase protection against 'the death of these cells.]"
They also found that although exercise increases protection of the heart,
it does not affect the improper cell death of endothelial cells.
Alpha-Lipoic and The Heart Muscle, Diabetes, Oxidative Stress, Atherosclerosis, Hypertension (high blood pressure,) Alzheimer's, Down's Syndrome, Anti-Obesity, Asthma & Multiple Sclerosis Bibliography
1. Expert Opinion Investig. Drugs, vol. 13, 2004. By: Dr. D. Doggrell, School of Biomedical Sciences of Queensland, Australia.
2. Archives of Gerontol. Geriatrics, vol. 29, 1999. By: Drs. Perricone, Nagy, Horvath, Uray, et. al., Dept. of Gerontology, Yale School of Med., New Haven, CT., U.S.A.
3. Neurochem Int., Jan. 2005. By: Drs. Poon, Lynn, Banks, Butterfield, et. al., Dept. of Chemistry, U. of Kentucky, Lexington, KY 40506-0055, U.S.A.
4. Clin. Exp. Hypertens. vol. 20, 2004. By: Drs. Champain, Girouard, Laplante, et. al., Dept. of Physiology, Faculty of Med., U. of Montreal, Montreal, Quebec, Canada.
5. Journal of Allergy & Clin. Immunol., vol. 114, 2004. By: Cho, Lee, Park & Moon, Div. of Allergy, U. Ursan College of Med., S. Korea. Only attenuated address given.
6. Journal Mol. Cell Cardiology, March 2005; vol. 38, pgs. 445-451. By: Drs. Marsh, Laursen, Pat, Gobe, Coombes, School of Human Movement Studies, U. of Queensland, Q4072 Brisbane, Australia.