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The Elderly and Muscle Wasting
Scientists recently* pointed out that a substance within us, ".... tumor
necrosis factor a (TNFa), originally part of a group of 'small proteins
which cause a catabolic--protein destroying--effect], is thought to play
a role in skeletal muscle wasting that occurs with chronic infections,
rheumatoid arthritis, cancer, and other chronic diseases."
These effects have been
shown in various studies with animals, one such experiment revealing
TNFa's supression of protein synthesis and another showing that it
"induces skeletal muscle protein breakdown...."
However, the scientists
reveal, ".... resistance exercise 'such as weight-lifting] may 'reduce]
this process by suppressing ....TNFa expression"
*Drs. Greiwe, Cheng,
Semenkovich et al, Depts. of Medicine and Cell Biology and Physiology,
Washington U. School of Medicine, St. Louis, MO 63110, in FASEB
Journal, volume 15, 2001.
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